Throwing shoes at President Bush started as a protest, then it became news, then parody, then games, then protests again, and now it has become commercial. eBay has an ad that suggest you should use them to get rid of a Christmas gift you don’t want. So the meme made the quickest transition ever from serious to silly.
The 20 second Bush Shoe eBay ad was apparently created by Belgium's Proximity BBDO ad agency. Has “jumping the shark” been replaced “by throwing the shoe?"