Following their 'Suicide' commercial, Heineken has another quirky one in the 'F_ck It' series.
A man comes back home from work with two Heineken beers (one for him and one for the wife) to find her blowing a guy in their bedroom. Rather than be angry or sad, the man realizes that this means he can have booth Heineken beers for himself. So he looks at them, smirks, and with a 'F_ck It', he opens a beer.
I dunno if this one is as effective as the suicide ad, but it sure is funny.
Check out Heineken's previous commercial: