Anti-Aging Drugs

 - Jun 6, 2008
References: sirtrispharma & blog.wired
You could soon be able to live a longer and, more importantly, healthier life with a little pharmaceutical help. The so-called "diseases of aging" such as cancer, diabetes, dementia, heart disease and other conditions greatly affect the quality of life in our twilight years. The reason so many people experience illness in their last several years is thought to be related to damage inflicted by free radicals on cellular mitochondria. These free radicals form when we inevitably change chemical energy derived from food into fuel for our bodies. The process has been described as age-related cellular breakdown.

One path to the fountain of youth, still unproven in humans, is to stick to calorie restricted diets. These diets have been shown to extend the lifespan of laboratory animals. However, the dietary discipline required is not an appealing option.

Pharmaceutical shortcuts are being developed where drugs target the particular genes activated by restricted calorie diets. One such drug is made by Sirtris Pharmaceuticals uses resveratrol which has been shown to protect lab animals from heart disease, cancer, Alzheimer's and Parkinson's diseases. Clinical studies on resveratrol's effects on humans are only just beginning. It is actually in Phase II clinical trials for diabetes. Scientists have previously found that diabetic mice given resveratrol became less diabetic as well as the added bonus of rejuvenated mitochondria.

Many pharmaceutical companies are investing in research into such products because anti-aging drugs are huge business. The pharmaceutical giant, GlaxoSmithKline, has just purchased Sirtris Pharmaceuticals for $720 million. David Sinclair, the co-founder of Sirtris Pharmaceuticals says these drugs "could have as big an impact as antibiotics in the 20th century, and it's just around the corner."