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Cancer-Resistant Mouse - Par-4 Gene Kills Cancer Cells
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The possibility of a world without cancer just got closer. Think about this: a mouse resistant to even the most aggressive types of cancer has been created by researchers at the University of Kentucky.
“The researchers discovered that the Par-4 gene kills cancer cells, but not normal cells,” Science Daily said. There are very few molecules that specifically fight against cancer cells, giving it a potentially therapeutic application.”
The gene was introduced to a mouse egg which was planted in a host mother.
“The mouse itself does not express a large number of copies of this gene, but the pups do and then their pups start expressing the gene,” Vivek Rangnekar, a professor of radiation medicine said. “So, we’ve been able to transfer this activity to generations in the mouse.”
The gene kills off cancer while the mice still grow normally, having no defects, and actually living a few months longer than control mice. There have been no indications of toxic side effects.
"We originally discovered Par-4 in the prostate, but it's not limited to the prostate. The gene is expressed in every cell type that we've looked at and it induces the death of a broad range of cancer cells, including of course, cancer cells in the prostate," said Rangnekar. "The interesting part of this study is that this killer gene is selective for killing cancer cells. It will not kill normal cells and there are very, very few selective molecules out there like this."
(sciencedaily)
Via: sciencedaily
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