The typical Razer gaming mouse will have 12 thumb buttons, which is fine for multiplayer online games on a large scale; however, for simpler RPG games, there's the Naga Hex Mouse.
As a response to RPG gamers, Razer developed the Naga Hex Mouse. Like the name "Hex" suggests, there are six buttons instead of the usual 12. As the company states, these were designed "for MOBA and action-RPG user interfaces." Since RPG games rely on a ton of clicking, the switches on the Naga Hex can withstand up to 10 million clicks and accurately register 250 clicks per minute. The mouse runs on Razer Synapse 2.0 service, a cloud-based software that will store all personal preferences and settings on a server that can be accessed any time.
It's a great ergonomic design built for a different type of gamer.