Greeting cards traditionally have been marketed towards women, so American Greetings spent six months analyzing the differences between male and female perceptions of humour. The Comedy Central line was made with men in mind, featuring the oft vulgar South Park characters. The crude cards are rolling out at Target stores in seven designs and will become available at American Greetings retailers next year.

Future designs will include characters from Reno 911 and Li'l Bush. Earlier this year, American Greetings targeted females when they introduced a line of cards featuring illustrations of comedian Ellen DeGeneres.