Age-Reversing Skincare Lines

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Zylö Therapeutics' Z-Pod Platform is Used to Power XXIV's twentyfour

— September 17, 2025 — Tech
Zylö Therapeutics has revealed that its patented Z-pod® delivery platform is featured in the launch of XXIV’s new skincare line, twentyfour. The debut includes two products powered by Y100™-loaded Z-pods®: StepZero™, a topical powder for age-reversal, and HYDRÍQ™, a hydrator designed for long-lasting moisture and anti-aging support.

Unlike traditional skincare formulas that fade within an hour, Z-pod® technology—licensed from the Albert Einstein College of Medicine—uses silica particles to release active ingredients steadily for 24+ hours.

The key ingredient, Y100™, was developed by YuvaBio after AI screening over 14,000 compounds. Derived from the amla tree, Y100™ targets mitochondrial dysfunction, a root cause of wrinkles and loss of elasticity identified in a 2017 study.

By combining sustained delivery with mitochondria-focused science, the twentyfour line introduces a new approach to skincare that keeps skin hydrated, firm, and refreshed longer.

Image Credit: Zylö Therapeutics

Trend Themes

  1. AI-assisted Ingredient Discovery — The use of AI to screen over 14,000 compounds for Y100™ highlights a surge in AI-assisted methods transforming ingredient discovery and development.
  2. Extended-release Skincare Technology — Innovations like the Z-pod® delivery system that provide prolonged release of active ingredients for 24+ hours are redefining expectations for skincare product longevity and effectiveness.
  3. Mitochondrial-targeted Skincare — By focusing on mitochondrial dysfunction as a key aging factor, this trend underscores an emerging focus on cellular health as a new frontier in anti-aging skincare.

Industry Implications

  1. AI-driven Biotech — The integration of artificial intelligence in biotech for compound discovery, exemplified by YuvaBio's AI screening, is opening new possibilities in targeted therapeutic development.
  2. Advanced Skincare Formulations — With innovations like the Z-pod® platform, the skincare industry is witnessing a shift towards formulations that emphasize extended efficacy and targeted delivery systems.
  3. Cosmeceuticals — The use of scientifically advanced ingredients like Y100™ derived from natural sources aligns with a broader cosmeceuticals trend emphasizing both beauty and health benefits.
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