The Swiftpoint Slider mouse from Simtrix is truly unique with an ingenious design. The mouse is designed to to be held between the thumb and index finger and slides right over the keys on your laptop, conveniently utilizing the whole keyboard as a mousepad.
According to the makers, "Swiftpoint technology combines innovations in hardware and software that enable a more intuitive and ergonomic method of interfacing with the computer across all hardware platforms, software applications and user environments. The Swiftpoint was designed to overcome the limitations and frustrations encountered with the traditional computer mouse. It also allows maximum flexibility and functionality across a diverse range of HCI environments."
Check out another unique mouse design, the finger mouse does not work on your keyboard, but it can work on your pants!