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Researchers Focus on Identifying Early Signs of Chronic Stress

— December 1, 2025 — Tech
A research team led by Elena Ghotbi, M.D.— a postdoctoral research fellow at Johns Hopkins University School of Medicine in Baltimore, Maryland — has developed an artificial intelligence tool capable of identifying a potential biological indicator of chronic stress through the analysis of standard medical imaging. The innovation was presented at the annual meeting of the Radiological Society of North America (RSNA).

This method applies a deep learning algorithm to retrospectively examine common chest CT scans, measuring the size of the adrenal glands to calculate an Adrenal Volume Index (AVI). The study, which utilized a large existing dataset that combined imaging with psychological surveys and physiological measurements, established correlations between a higher AVI and elevated cortisol levels, greater allostatic load, and increased scores on stress questionnaires. Significantly, the research also linked increases in this index to a heightened long-term risk of serious health events, specifically heart failure and mortality, over a follow-up period spanning up to a decade.

Image Credit: RSNA

Trend Themes

  1. AI-driven Health Diagnostics — AI tools analyzing standard medical imaging to identify biological indicators of chronic stress represent a leap in non-invasive diagnostics.
  2. Predictive Health Monitoring — Utilizing AI to predict long-term health risks through indicators like the Adrenal Volume Index offers potential for preemptive healthcare strategies.
  3. Integrative Data Analysis — Combining imaging data with psychological and physiological datasets allows for a comprehensive view of patient health, paving the way for personalized treatment approaches.

Industry Implications

  1. Medical Imaging — Innovations in analyzing CT scans with AI can transform the way chronic stress is diagnosed and managed within medical imaging.
  2. Digital Health Technology — The integration of AI tools into health monitoring systems is revolutionizing how chronic conditions are identified and managed, creating new market opportunities in the digital health sphere.
  3. Healthcare Predictive Analytics — Harnessing advanced analytics for early detection of health conditions offers vast potential within predictive healthcare solutions.
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