# Garlic-Derived Muscle Health Compounds Wakunaga of America Researches a Garlic-Derived Compound By Kalin Ned | Published 2026-05-11 | Lifestyle Source: Trend Hunter, https://www.trendhunter.com/trends/wakunaga-of-america References: [news-medical.net](https://www.news-medical.net/news/20260507/Garlic-derived-compound-may-help-improve-muscle-strength-during-aging.aspx)  Wakunaga of America has announced that a specific compound found in Kyolic Aged Garlic Extract — known as S-1-propenyl-L-cysteine or S1PC — demonstrated in a peer-reviewed study the ability to counteract [skeletal muscle aging](https://www.trendhunter.com/trends/myoplex-glplex1-complex) by activating an inter-organ communication pathway that connects fat tissue to the brain, which then enhances signalling to muscles. Published in Cell Metabolism, the research showed that long-term S1PC treatments in aged mice produced significantly increased skeletal muscle force, restored body temperatures to youthful levels, and reduced overall frailty index scores. A randomized double-blind clinical trial in healthy middle-aged humans found that a single oral dose of S1PC-enriched garlic powder successfully increased circulating levels of the key enzyme eNAMPT in subjects with healthy body fat mass. Wakunaga of America is a company with a decades-long history of researching [medicinal herbs](https://www.trendhunter.com/trends/naka-herbs-vitamins-nattokinase-supplement). Image Credit: Wakunaga of America ## Trend Insights (Trend Hunter) - Score: 4.9/10 - Popularity: 35% | Activity: 40% | Freshness: 72% - Audience gender: 50% men, 50% women - Primary generations: Gen X - Top markets: North America ## Categories [Trend Hunter](https://www.trendhunter.com/trends) > [Lifestyle](https://www.trendhunter.com/lifestyle) > [Health](https://www.trendhunter.com/health) ## Key Themes ### What's Driving This Trend - **Garlic-derived Bioactives:** Discovery of S1PC highlights small-molecule organosulfur compounds as a new class of bioactives that could redefine natural-product pipelines for muscle-support therapeutics. - **Inter-organ Signaling Therapeutics:** Research linking adipose-to-brain-to-muscle communication reveals signaling pathways as therapeutic targets that could enable drugs or biologics to systemically reverse age-related muscle decline. - **Nutraceuticals for Sarcopenia:** Clinical evidence of an oral garlic-derived ingredient increasing eNAMPT levels suggests evidence-backed nutraceuticals may compete with conventional interventions for preserving muscle function in aging populations. ### Who This Affects Most - **Pharmaceuticals:** Translating S1PC mechanisms into synthetic analogs or repurposed drugs presents opportunities for new prescription treatments addressing frailty and sarcopenia. - **Nutraceuticals and Supplements:** Companies producing standardized, clinically validated garlic formulations could disrupt supplement markets by offering measurable biomarker-responsive products for middle-aged and elderly consumers. - **Functional Food Manufacturing:** Incorporation of S1PC-enriched ingredients into fortified foods offers possibilities for mainstream dietary products that deliver clinically relevant muscle-support benefits. ## Related on Trend Hunter - [Healthy Aging Gummies](https://www.trendhunter.com/trends/healthy-aging-gummies.md) - [Next-Generation Creatine Supplement Systems](https://www.trendhunter.com/trends/musclebuilding-system.md) - [Natural UV-Blocking Bioactives](https://www.trendhunter.com/trends/stress-activated-cyanobacterial-uv.md) - [Coffee-Derived Flavor Enhancers](https://www.trendhunter.com/trends/coffee-based-kokumi-ingredient.md) - [Black Garlic Hair Capsules](https://www.trendhunter.com/trends/tara.md) - [Post-Exercise Recovery Packs](https://www.trendhunter.com/trends/oxidoms.md) - [Peptide-Drug Conjugate Actives](https://www.trendhunter.com/trends/shenzhen-winkey.md) - [Antioxidant-Powered Advanced Skin Multivitamins](https://www.trendhunter.com/trends/advanced-skin-multivitamin.md) - [Functional Rice Bran Compounds](https://www.trendhunter.com/trends/rice-bran.md)