# Plant-Based Skin Actives Naolys Reinvests in the Science Behind Its Best-Selling Soothing Active By Grace Mahas | Written with AI assistance | Published 2026-02-24 | Fashion Source: Trend Hunter, https://www.trendhunter.com/trends/soothing-light-apple-tree References: [cosmeticsbusiness](https://cosmeticsbusiness.com/how-new-science-reinforces-naolys-soothing-best-seller)  French biotech company [Naolys](https://www.trendhunter.com/trends/naolys) has spent over 15 years refining its apple tree cell-based active, Soothing Light Apple, which has long been a go-to ingredient for formulations targeting sensitive skin. Now, the brand is deepening its scientific foundation with new 7-day clinical evaluations and [AI-based skin analysis tools](https://www.trendhunter.com/trends/skincare-ingredient) that track early skin responses with greater precision than previous testing methods allowed. Central to this updated research is a closer look at the [plant-derived PDRNs](https://www.trendhunter.com/trends/plantbased-exosome) naturally occurring in Malus domestica cells. These compounds play a measurable role in reinforcing the skin barrier, which tends to be the primary vulnerability in sensitive skin types. Notably, the plant-based PDRNs serve as a viable alternative to animal-derived versions, aligning with the industry's broader shift toward ethical sourcing. Made in France, the active reflects Naolys' ongoing commitment to marrying rigorous science with responsible ingredient development. ## Trend Insights (Trend Hunter) - Score: 5.2/10 - Popularity: 38% | Activity: 53% | Freshness: 66% - Audience gender: 50% men, 50% women - Primary generations: Millennial, Gen X - Top markets: North America, Europe, Asia ## Categories [Trend Hunter](https://www.trendhunter.com/trends) > [Fashion](https://www.trendhunter.com/fashion) > [Cosmetics](https://www.trendhunter.com/cosmetics) ## Key Themes ### What Makes This Trend Stand Out - **AI-driven Skin Analysis:** New AI tools that detect early skin responses enable the development of faster, more personalized efficacy claims for actives and formulations. - **Plant-derived Pdrns:** Plant-sourced PDRNs from Malus domestica present a cruelty-free biochemical alternative to animal-derived nucleotides with comparable barrier-reinforcing potential. - **Short-term Clinical Precision:** Seven-day clinical evaluations combined with advanced analytics are shifting product validation toward quicker, high-confidence performance signals. ### Sectors Adopting This - **Skincare Manufacturing:** Formulators and brands can leverage validated plant actives and rapid clinical readouts to differentiate sensitive-skin product lines with science-backed positioning. - **Biotech Research Tools:** Providers of AI imaging, skin analytics, and molecular assays stand to redefine R&D workflows by enabling earlier go/no-go decisions and finer mechanistic insight. - **Ingredient Sourcing and Supply Chain:** Suppliers emphasizing traceable, French-made plant actives and ethical PDRN production can capture demand from brands prioritizing provenance and sustainability. ## Related on Trend Hunter - [AI-Powered Skincare Analyzers](https://www.trendhunter.com/trends/skin-light-therapy-3s.md) - [Light-Activated Skincare Serums](https://www.trendhunter.com/trends/mitoaura-activate-amplify-serum.md) - [Skin Cell Renewal Treaments](https://www.trendhunter.com/trends/nad-cell-energizing-treatment.md) - [Neuroscience-Inspired Overnight Skincare](https://www.trendhunter.com/trends/the-sleeping-mask.md) - [Multi-Action Soothing Serums](https://www.trendhunter.com/trends/7x-calming-complex.md) - [Carcadium Rhythm-Supporting Creams](https://www.trendhunter.com/trends/protective-day-cream.md) - [Korean Skincare Debuts](https://www.trendhunter.com/trends/hanyul-2.md) - [Moisturizing Skin-Calming Cosmetics](https://www.trendhunter.com/trends/aveeno-products.md) - [Exfoliating Daily Moisturizers](https://www.trendhunter.com/trends/amlactin.md)