# Oral Inflammatory Disease Treatments Gilead Acquires PepStar's Investigational IL-23R Inhibitor By Mursal Rahman | Written with AI assistance | Published 2026-10-26 | Tech Source: Trend Hunter, https://www.trendhunter.com/trends/oral-inflammatory-disease-treatments References: [medcitynews](https://medcitynews.com/2026/10/gilead-sciences-oral-peptide-il-23-inhibitor-pepstar-immunology-inflammation-ibd-gild) & [investors.gilead](https://investors.gilead.com/news/news-details/2026/Gilead-to-Acquire-Investigational-Oral-IL-23R-Inhibitor-HCXT-2001-Strengthening-Its-Inflammation-Pipeline-in-IBD/default.aspx)  Gilead Sciences is expanding its development of oral inflammatory disease treatments through an agreement to acquire PepStar Therapeutics' HCXT-2001 program. The experimental medicine uses a macrocyclic peptide to block the IL-23 receptor, which plays a role in immune-related inflammatory conditions. Its extended half-life could support convenient daily dosing for patients with inflammatory bowel disease. Currently undergoing Phase 1 clinical trials, HCXT-2001 may eventually be investigated as a standalone therapy or combined with Gilead's emvistegrast. Researchers are also exploring its potential applications in psoriasis. However, the treatment has not received regulatory approval, and its safety and effectiveness remain unconfirmed. The $1.275 billion acquisition would give Gilead worldwide rights to the program, strengthening its position in inflammation research. Adding another treatment mechanism could broaden the company's development options and support future combination therapies targeting unmet patient needs. Image Credit: Gilead Sciences ## Trend Insights (Trend Hunter) - Score: 9.5/10 - Popularity: 92% | Activity: 92% | Freshness: 100% - Audience gender: 50% men, 50% women - Primary generations: Millennial, Gen X - Top markets: North America, Asia ## Categories [Trend Hunter](https://www.trendhunter.com/trends) > [Tech](https://www.trendhunter.com/tech) > [Science](https://www.trendhunter.com/science) ## Key Themes ### What Makes This Trend Stand Out - **Oral Immunology Therapeutics:** Daily oral treatments for immune-mediated diseases create openings for patient-friendly alternatives to injectable biologics in chronic inflammation care. - **Macrocyclic Peptide Medicines:** Macrocyclic peptide platforms combine biologic-like targeting with small-molecule convenience, reshaping how drug developers approach difficult inflammatory pathways. - **Combination Inflammation Regimens:** Pairing complementary mechanisms such as IL-23R inhibition and integrin targeting may expand differentiated treatment options for complex autoimmune conditions. ### Sectors Adopting This - **Biopharmaceuticals:** Large-scale acquisitions of investigational inflammation assets reflect growing commercial interest in next-generation oral therapies with broad pipeline potential. - **Gastroenterology:** Inflammatory bowel disease care stands to be transformed by convenient oral regimens that could improve adherence and compete with infusion-based standards. - **Dermatology:** Psoriasis research may benefit from new oral immune pathway inhibitors that offer differentiated positioning in a crowded biologics-driven market. ## Related on Trend Hunter - [Treatment-Resistant Depression Acquisitions](https://www.trendhunter.com/trends/eli-lilly-and-company.md) - [AI Drug Discovery](https://www.trendhunter.com/trends/AI-drug-discovery.md) - [AI-Driven Discovery Platforms](https://www.trendhunter.com/trends/Pharma-AI-suite.md) - [Needle-Free Peptide Therapies](https://www.trendhunter.com/trends/needle-free-peptide-therapies.md) - [Prescription Digital Therapeutics](https://www.trendhunter.com/trends/ct.md) - [Anti-Inflammatory Agent Studies](https://www.trendhunter.com/trends/antiinflammatory-agent.md) - [Weight-Management Program Expansions](https://www.trendhunter.com/trends/suite-of-wellness-solutions.md) - [Targeted Rare Disease Therapies](https://www.trendhunter.com/trends/reduces-new-bone-growth.md) - [GLP-1 Medication-Offering Health Platforms](https://www.trendhunter.com/trends/futurhealth.md)