# Microbiome-Based Bone Health Research Pendulum Therapeutics Expands Collaboration with Mayo Clinic By Kalin Ned | Published 2026-05-15 | Lifestyle Source: Trend Hunter, https://www.trendhunter.com/trends/bone-health References: [prnewswire](https://www.prnewswire.com/news-releases/pendulum-therapeutics-expands-clinical-collaboration-to-advance-microbiome-research-in-womens-health-and-dermatology-302739314.html)  [Pendulum Therapeutics](https://www.trendhunter.com/trends/pendulum-metabolic-daily) has expanded its clinical research collaboration with [Mayo Clinic](https://www.trendhunter.com/trends/jogo-health), one of the most respected medical institutions in the world, to investigate microbiome-based interventions for bone health in breast cancer patients, the gut-skin axis, and improving the menopause transition. This announcement builds on a relationship that began in 2013. As part of the inquiry into bone health, gut-skin axis, and menopause transition, the research collaboration relies on Pendulum's portfolio of microbiome-targeted products along with its expertise in strain isolation, anaerobic manufacturing, DNA sequencing, and clinical validation. Mayo Clinic investigators will evaluate these new clinical studies. Pendulum already has a track record of rigorous clinical research, having developed Glucose Control, the first probiotic clinically shown to reduce A1C in people with type 2 diabetes. Image Credit: Pendulum Therapeutics ## Trend Insights (Trend Hunter) - Score: 7.1/10 - Popularity: 66% | Activity: 70% | Freshness: 77% - Audience gender: 10% men, 90% women - Primary generations: Gen X - Top markets: North America ## Categories [Trend Hunter](https://www.trendhunter.com/trends) > [Lifestyle](https://www.trendhunter.com/lifestyle) > [Health](https://www.trendhunter.com/health) ## Key Themes ### Key Themes Behind This Trend - **Microbiome-driven Therapeutics:** Emerging designer probiotic formulations and strain-specific biologics that modulate host physiology present opportunities to redefine treatment paradigms across chronic conditions. - **Biotech-medical Center Collaborations:** Expanded partnerships between specialty startups and leading hospitals enable integrated clinical validation pathways that can accelerate translational research and regulatory acceptance. - **Women-centric Microbiome Interventions:** Targeted microbiome approaches addressing menopause and breast-cancer–related bone health introduce potential for new therapeutic categories tailored to female life-stage physiology. ### Where This Applies - **Pharmaceuticals:** Novel live-biotherapeutic products and strain-derived small molecules could disrupt traditional drug pipelines by introducing microbiome-native modalities with distinct regulatory profiles. - **Precision Nutrition:** Personalized, clinically validated probiotic and prebiotic regimens informed by sequencing data offer the potential to shift nutrition from general guidance to medically actionable interventions. - **Clinical Diagnostics:** Advanced microbiome sequencing and biomarker panels have the capacity to create new diagnostic classes that predict treatment response and monitor therapy efficacy in real time. ## Related on Trend Hunter - [Human Microbiome-Powered Meditation Experiences](https://www.trendhunter.com/trends/microbiomepowered.md) - [Advanced Gut Microbiome Tests](https://www.trendhunter.com/trends/advanced-gut-microbiome-test.md) - [Longevity-Focused Microbiome Tests](https://www.trendhunter.com/trends/tiny-healths.md) - [At-Home Microbiome Tests](https://www.trendhunter.com/trends/tiny-health.md) - [Flavorless Gut Support Powders](https://www.trendhunter.com/trends/pendulum-therapeutics-gut-fuel.md) - [Biotech Beauty Partnerships](https://www.trendhunter.com/trends/biotech-beauty-partnerships.md) - [Rejuvenating Microbiome-Supporting Supplements](https://www.trendhunter.com/trends/microbiome-rejuvenate.md) - [Microbiome Skincare Pharmacy Rollouts](https://www.trendhunter.com/trends/gallinee-1.md) - [Menopause Care Research Initiatives](https://www.trendhunter.com/trends/menopause-care.md)