Regrowing Limbs - Salamander-Like Healing For Humans (GALLERY)

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Dee Sandin
On: Mar 17, 08
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Regrowing Limbs - Salamander-Like Healing For Humans (GALLERY) [Edit]


Regrowing Limbs - Salamander-Like Healing For Humans (GALLERY)
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Researchers are trying to understand limb regeneration by studying salamanders, as they think the reptiles could hold the key to regeneration for human limbs.

Salamanders can regrow lost body parts where as human tissue forms a scar. The trick is to learn to control the human wound area, triggering the salamander-like healing process in order to make it possible to regrow body parts. Repairing damaged organs and regenerative medicine, is a hot topic with pretty much all the attention focused on growing stem cells outside the body, turning them into a specific type of tissue to transplant into patients. But some scientists believe a better approach is to induce the regeneration process of salamanders into people. This natural regeneration, accomplished with drugs or genes, will be much easier than transplanting.

“I really do believe it’s just a matter of time before you’re going to regenerate an arm or at least a finger,” said Dr. David M. Gardiner, a biologist who runs the laboratory at the University of California at Irvine with Dr. Susan V. Bryant, the dean of biological sciences and his wife. “I’d like to see that in my lifetime.”

Humans have long wondered how the salamander pulls off this feat. How does the regrowing part of the limb “know” how much limb is missing and needs to be replaced? Why doesn’t the skin at the stump form a scar to seal off the wound as it would in humans? How can adult salamander tissue retain the embryonic potential to build an entire limb from scratch multiple times? Biologists are closing in on the answers to those questions. And if we can understand how the regeneration process works in nature, we hope to be able to trigger it in people to regenerate amputated limbs, for example, and transform the healing of other major wounds. "I'd like to say we've made tremendous progress, but that would be a lie," said Dr. Catherine Tsilfidis, an assistant professor at the University of Ottawa Eye Institute, who is studying regeneration in newts. Now, though, genetic techniques are starting to allow scientists to fathom the mechanisms of regeneration. That and the excitement surrounding regenerative medicine are creating new scientific and even commercial interest in regeneration. (propeller)




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